Gazetopoulos N, Ioannidis P J, Karydis C, Lolas C, Kiriakou K, Tountas C
Br Heart J. 1976 Nov;38(11):1160-5. doi: 10.1136/hrt.38.11.1160.
The relation between the length of the main left coronary artery and the degree of atherosclerosis in its branches was studied by postmortem examination in 204 subjects aged 20 to 90 years. The findings suggest that in cases with a short main left coronary artery the atherosclerotic lesions in the anterior descending and circumflex branches appear earlier, progress faster at higher levels of severity, and lead more frequently to myocardial infarction, than in cases with a long left coronary artery trunk. In cases over the age of 50 years, where disease is expected to have developed, it was shown that the degree of atherosclerosis in the left anterior descending and circumflex branches was inversely related to the length of the main left coronary artery. The correlation coefficients were -0-527 and -0-428, respectively, and in either case a test for zero correlations was significant (P less than 0-001). The possible changes in the haemodynamic and mechanical conditions associated with the variations of the anatomical pattern of the coronary arteries and their influence in the development of atherosclerosis are discussed. It is suggested that the length of the main left coronary artery is a congenital anatomical and possibly hereditary factor influencing the rate of development of atherosclerosis in the branches of the main left coronary artery.
通过对204名年龄在20至90岁的受试者进行尸检，研究了左冠状动脉主干长度与其分支动脉粥样硬化程度之间的关系。研究结果表明，与左冠状动脉主干较长的情况相比，左冠状动脉主干较短的情况下，前降支和回旋支的动脉粥样硬化病变出现更早，在更高严重程度水平上进展更快，并且更频繁地导致心肌梗死。在预计已发生疾病的50岁以上人群中，研究表明左前降支和回旋支的动脉粥样硬化程度与左冠状动脉主干长度呈负相关。相关系数分别为-0.527和-0.428，在这两种情况下，零相关性检验均具有显著性（P小于0.001）。文中讨论了与冠状动脉解剖模式变化相关的血流动力学和力学条件的可能变化及其对动脉粥样硬化发展的影响。研究表明，左冠状动脉主干长度是一个先天性解剖因素，可能也是影响左冠状动脉主干分支动脉粥样硬化发展速度的遗传因素。
