Brinkman A M, Baker P B, Newman W P, Vigorito R, Friedman M H
Biomedical Engineering Center, Ohio State University, Columbus 43210.
Ann Biomed Eng. 1994 Jan-Feb;22(1):34-44. doi: 10.1007/BF02368220.
A computer-based system is described to measure objectively the geometric parameters of arteries from pairs of projection angiograms. This technique, which employs back-projection to define the vessel axes in 3-D space, was used to obtain selected parameters of coronary artery geometry from radiographic images of autopsy hearts. Results of the first 30 cases are presented, focussing on the distribution of the geometric parameters of the left anterior descending coronary artery (LAD) and its first two major branches. The derived parameters include the angle between the left circumflex artery and the LAD; the angles between the LAD and its early diagonal and septal perforator branches; distances between branch points; and tortuosity. The geometric parameters vary considerably, presumably contributing to a corresponding variability in local hemodynamic and mechanical stresses. Most parameters are uncorrelated. One exception is the angle at the origin of the second diagonal branch, which is positively correlated (p < 0.01) with the distance between the ostia of the first two diagonal vessels; this correlation could reflect the existence of "target" perfusion regions. No relation between geometric parameters and age or gender was seen. In this sample, blacks had a larger angle at the left main bifurcation than whites (p < 0.05).
描述了一种基于计算机的系统，用于从成对的投影血管造影图像中客观测量动脉的几何参数。该技术采用反投影来定义三维空间中的血管轴，用于从尸检心脏的放射图像中获取冠状动脉几何形状的选定参数。给出了前30例的结果，重点关注左前降支冠状动脉（LAD）及其前两个主要分支的几何参数分布。导出的参数包括左旋支动脉与LAD之间的夹角；LAD与其早期对角支和间隔穿支之间的夹角；分支点之间的距离；以及弯曲度。几何参数变化很大，可能导致局部血流动力学和机械应力相应变化。大多数参数不相关。一个例外是第二对角支起始处的角度，它与前两个对角血管开口之间的距离呈正相关（p<0.01）；这种相关性可能反映了“目标”灌注区域的存在。未发现几何参数与年龄或性别之间的关系。在这个样本中，黑人左主分叉处的角度比白人更大（p<0.05）。
