Leteurtre E, Boman F, Gosselin B
Service d'Anatomie et de Cytologie Pathologiques, Hôpital Calmette, CHRU, Lille.
Arch Anat Cytol Pathol. 1999;47(1):44-7.
Biotin-rich pseudoherpetic nuclear inclusions may be observed in endometrial epithelial cells during pregnancy, post-partum or in association with choriocarcinoma. They may be observed in tumor cells in a few papillary carcinomas of the thyroid gland in young women. These inclusions may be responsible for false diagnoses of herpesvirus infection at morphological and immunocytochemical examination. They may be responsible for false positives in immunocytochemistry and in situ hybridization.
富含生物素的假疱疹样核内包涵体可见于孕期、产后的子宫内膜上皮细胞中，或与绒毛膜癌相关。在年轻女性的少数甲状腺乳头状癌的肿瘤细胞中也可观察到。在形态学和免疫细胞化学检查中，这些包涵体可能导致对疱疹病毒感染的误诊。它们可能导致免疫细胞化学和原位杂交出现假阳性结果。
