Chen L W, Sun J H, Liu P P
Department of Surgery, Veterans Hospital-Kaohsiung, Taiwan, Republic of China.
Kaohsiung J Med Sci. 1999 Feb;15(2):113-8.
HPLC with EC detector was used to study the red light effect on the rhythmicity of catecholamines (NE, DOPAC and dopamine) and indoleamines (NAS, 5-HT, 5-HIAA) in the pineal glands and retinas of the Sprague-Dawley rat. We found the prominent nocturnal elevations of NAS in rat pineal glands and the suppression of the NAS but not the elevation of 5-HT and 5-HIAA after red light exposure at night. Our data show two findings: metabolic pathway of the indoleamines (5-HT, 5-HIAA and NAS) after red light exposure at night may be different from those by white light. Second, the increased HIOMT activity that effects on 5-HT and 5-HIAA may also be involved in the indoleamine formation after red light exposure at night.
采用高效液相色谱法结合电化学检测器，研究红光对斯普拉格-道利大鼠松果体和视网膜中儿茶酚胺（去甲肾上腺素、二羟基苯乙酸和多巴胺）以及吲哚胺（N-乙酰血清素、5-羟色胺、5-羟吲哚乙酸）节律性的影响。我们发现大鼠松果体中N-乙酰血清素在夜间显著升高，且夜间红光照射后N-乙酰血清素受到抑制，但5-羟色胺和5-羟吲哚乙酸并未升高。我们的数据显示出两个结果：夜间红光照射后吲哚胺（5-羟色胺、5-羟吲哚乙酸和N-乙酰血清素）的代谢途径可能与白光照射后的不同。其次，影响5-羟色胺和5-羟吲哚乙酸的羟吲哚-O-甲基转移酶活性增加，可能也参与了夜间红光照射后的吲哚胺形成过程。
