利用光学相干断层扫描技术对正常及骨关节炎软骨进行高分辨率成像。
High resolution imaging of normal and osteoarthritic cartilage with optical coherence tomography.
作者信息
Herrmann J M, Pitris C, Bouma B E, Boppart S A, Jesser C A, Stamper D L, Fujimoto J G, Brezinski M E
机构信息
Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge 02139, USA.
出版信息
J Rheumatol. 1999 Mar;26(3):627-35.
OBJECTIVE
We describe optical coherence tomography (OCT), a high resolution micron scale imaging technology, for assessment of osteoarthritic articular cartilage microstructure. OCT is analogous to ultrasound, measuring the intensity of backreflected infrared light rather than acoustical waves.
METHODS
OCT imaging was performed on over 100 sites on 20 normal and osteoarthritic cartilage specimens in vitro.
RESULTS
Microstructures that were identified included fibrillations, fibrosis, cartilage thickness, and new bone growth at resolutions between 5 and 15 microm. In addition, the polarization sensitivity of imaging suggested a diagnostic role of polarization spectroscopy.
CONCLUSION
OCT represents an attractive new technology for intraarticular imaging due to its high resolution (greater than any available clinical technology), ability to be integrated into small arthroscopes, compact portable design, and relatively low cost.
目的
我们描述了光学相干断层扫描（OCT），一种高分辨率微米级成像技术，用于评估骨关节炎关节软骨的微观结构。OCT类似于超声，测量背向反射红外光而非声波的强度。
方法
对20个正常和骨关节炎软骨标本上的100多个部位进行了体外OCT成像。
结果
识别出的微观结构包括纤维形成、纤维化、软骨厚度以及分辨率在5至15微米之间的新骨生长。此外，成像的偏振敏感性提示了偏振光谱的诊断作用。
结论
由于其高分辨率（高于任何现有的临床技术）、能够集成到小型关节镜中、紧凑便携的设计以及相对较低的成本，OCT是一种用于关节内成像的有吸引力的新技术。
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