Owen J, Hauth J C
Department of Obstetrics and Gynecology, University of Alabama at Birmingham, 35233-7333, USA.
J Matern Fetal Med. 1999 Mar-Apr;8(2):48-50. doi: 10.1002/(SICI)1520-6661(199903/04)8:2<48::AID-MFM3>3.0.CO;2-F.
To examine the efficacy of vaginal misoprostol for mid-trimester pregnancy termination.
This randomized trial compared misoprostol, 200 microg per vaginum q 12 h to a protocol of concentrated oxytocin plus low-dose vaginal prostaglandin E2 suppositories (10 mg q 6 h). Success was defined as an induction-to-delivery interval < or =24 h.
Interim analysis of the first 30 (15-misoprostol, 15-concentrated oxytocin) women demonstrated that the 2 groups were similar with regard to indication for delivery, gestational age, and demographic characteristics. Misoprostol was associated with a lower success rate (67 vs. 87%, P = .2), a longer induction-delivery interval (22 h vs. 18 h, P = .09), a higher rate of retained placenta requiring curettage (27 vs. 13%, P = .65), and a higher live birth rate (50 vs. 0%, P = .006).
Compared to a regimen of concentrated oxytocin plus low-dose prostaglandin E2, misoprostol administered as vaginal tablets in a dose of 200 microg q 12 h is not satisfactory for mid-trimester pregnancy termination in an unselected population.
探讨阴道用米索前列醇用于孕中期引产的疗效。
本随机试验将每12小时阴道给予200微克米索前列醇与浓缩催产素加低剂量阴道用前列腺素E2栓剂（每6小时10毫克）的方案进行比较。成功定义为引产至分娩间隔≤24小时。
对前30名女性（15名使用米索前列醇，15名使用浓缩催产素）的中期分析表明，两组在分娩指征、孕周和人口统计学特征方面相似。米索前列醇组的成功率较低（67%对87%，P = 0.2），引产至分娩间隔较长（22小时对18小时，P = 0.09），需要刮宫的胎盘残留率较高（27%对13%，P = 0.65），活产率较高（50%对0%，P = 0.006）。
与浓缩催产素加低剂量前列腺素E2方案相比，每12小时阴道给予200微克米索前列醇片剂用于未选择人群的孕中期引产效果不佳。
