Owen J, Hauth J C
Department of Obstetrics and Gynecology, University of Alabama at Birmingham, USA.
Obstet Gynecol. 1996 Jul;88(1):110-3. doi: 10.1016/0029-7844(96)00132-9.
To examine the efficacy and side effects of concentrated oxytocin plus low-dose prostaglandin (PG) E2 compared with a standard dose of vaginal PGE2 for second-trimester pregnancy termination.
Patients with obstetric or fetal complications were randomly assigned to receive either a 20-mg PGE2 vaginal suppository every 4 hours (n = 81) or a concentrated oxytocin infusion plus a 10-mg PGE2 vaginal suppository every 6 hours (n = 73). Treatment success was defined as delivery (or imminent delivery) within 24 hours of therapy. Women who failed their assigned regimen were crossed to the alternate method.
Indications for delivery were similar in the two groups. The success rate with oxytocin was 89%, compared with 81% with vaginal PGE2 (relative risk 0.92, 95% confidence interval 0.8-1.04; P = .2). Maternal fever (P < .001), nausea (P = .02), and vomiting (P = .003) occurred significantly more often in women who received a 20-mg PGE2 vaginal suppository every 4 hours.
Concentrated oxytocin plus low-dose PGE2 should be considered as an alternative to vaginal PGE2 for indicated second-trimester pregnancy termination.
探讨浓缩催产素加小剂量前列腺素（PG）E2与标准剂量阴道用PGE2用于中期妊娠终止的疗效及副作用。
将有产科或胎儿并发症的患者随机分为两组，一组每4小时接受一次20毫克PGE2阴道栓剂（n = 81），另一组每6小时接受一次浓缩催产素输注加10毫克PGE2阴道栓剂（n = 73）。治疗成功定义为在治疗24小时内分娩（或即将分娩）。未成功完成指定治疗方案的女性改用另一种方法。
两组的分娩指征相似。催产素组的成功率为89%，而阴道用PGE2组为81%（相对风险0.92，95%置信区间0.8 - 1.04；P = 0.2）。每4小时接受一次20毫克PGE2阴道栓剂的女性中，产妇发热（P < 0.001）、恶心（P = 0.02）和呕吐（P = 0.003）的发生率明显更高。
对于有指征的中期妊娠终止，浓缩催产素加小剂量PGE2应被视为阴道用PGE2的替代方法。
