Martins A N, Doyle T F
Stroke. 1978 Sep-Oct;9(5):509-13. doi: 10.1161/01.str.9.5.509.
A focal cryogenic lesion was made in the left superior frontal gyrus of the anesthetized macaque brain. Cerebral blood flow (CBF) was determined by the hydrogen clearance technique before and during the 4 hours following trauma. Local CBF in tissue adjacent to the lesion increased in the first half hour after the lesion was made and then decreased during the ensuing 3 1/2 hours. Local CBF in the contralateral superior frontal gyrus, as well as total CBF and oxygen consumption, were unchanged by cryogenic trauma. The spread of vasogenic edema into uninjured tissue probably accounts for the observed decrease in local CBF. This experimental model may assist in discovering therapy to alter favorably the spatial and temporal profile of pathologic CBF changes in tissue surrounding an acute lesion of the brain.
在麻醉的猕猴大脑左额上回制造一个局灶性低温损伤。在创伤前及创伤后4小时内，通过氢清除技术测定脑血流量（CBF）。损伤后半小时内，损伤邻近组织的局部CBF增加，随后在接下来的3个半小时内下降。低温创伤对同侧额上回的局部CBF以及总CBF和氧消耗没有影响。血管源性水肿扩散到未损伤组织中可能是观察到的局部CBF下降的原因。该实验模型可能有助于发现能有利改变急性脑损伤周围组织病理性CBF变化的时空特征的治疗方法。
