Neher E
Max-Planck-Institut für biophysikalische Chemie, Göttingen, Germany.
Cell Calcium. 1998 Nov-Dec;24(5-6):345-57. doi: 10.1016/s0143-4160(98)90058-6.
Simple approximations to some limiting cases of Ca++ signalling provide insight into the complex problems of buffered diffusion and of Ca++ homeostasis in the presence of buffers. Three cases are presented, where the influence of Ca++ buffers can readily be understood in the limit of small signals: the return of global cellular [Ca++] following a short stimulus in a 'Single Compartment', buffered diffusion along a cylindrical axon in the 'Rapid Buffer Approximation', and nonequilibrium microdomains of elevated [Ca++] in the immediate vicinity of open Ca++ channels.
对钙离子信号传导某些极限情况的简单近似，有助于深入理解存在缓冲剂时缓冲扩散和钙离子稳态的复杂问题。本文介绍了三种情况，在小信号极限下，钙离子缓冲剂的影响很容易理解：“单隔室”中短刺激后细胞内钙离子浓度的恢复、“快速缓冲近似”下沿圆柱形轴突的缓冲扩散，以及开放钙离子通道紧邻区域内钙离子浓度升高的非平衡微区。
