Raz T, Shalgi R
Department of Embryology and Teratology, Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, Israel.
Hum Reprod. 1998 Dec;13 Suppl 4:133-45. doi: 10.1093/humrep/13.suppl_4.133.
The fertilizing spermatozoon initiates a series of events in the mammalian egg, referred to as 'egg activation'. These biochemical and morphological events include a transient rise in intracellular Ca2+ concentration ([Ca2+]i) that leads to the cortical reaction (CR) and the establishment of the block to polyspermy on the one hand, and to the resumption of meiosis and later embryonic mitotic divisions on the other. The initial increase in [Ca2+]i appears to be critical for the initiation of egg activation. However, another second messenger, protein kinase C (PKC), was also suggested as a possible inducer of some aspects of egg activation. The review focuses on early events during mammalian sperm-egg interaction and discusses possible roles of Ca2+ and PKC in egg activation.
受精精子在哺乳动物卵子中引发一系列事件，称为“卵子激活”。这些生化和形态学事件包括细胞内Ca2+浓度（[Ca2+]i）的短暂升高，一方面导致皮质反应（CR）和多精受精阻断的建立，另一方面导致减数分裂的恢复以及随后的胚胎有丝分裂。[Ca2+]i的初始增加似乎对卵子激活的启动至关重要。然而，另一种第二信使蛋白激酶C（PKC）也被认为可能是卵子激活某些方面的诱导剂。本文综述聚焦于哺乳动物精卵相互作用的早期事件，并讨论了Ca2+和PKC在卵子激活中的可能作用。
