A software implementation for detailed volume conductor modelling in electrophysiology using finite difference method.

There is an evolving need for new information available by employing patient tailored anatomically accurate computer models of the electrical properties of the human body. Because construction of a computer model can be difficult and laborious to perform sufficiently well, devised models have varied greatly in the level of anatomical accuracy incorporated in them. This has restricted the validity of conducted simulations. In the present study, a versatile software package was developed to transform anatomic voxel data into accurate finite difference method volume conductor models conveniently and in a short time. The package includes components for model construction, simulation, visualisation and detailed analysis of simulation output based on volume conductor theory. Due to the methods developed, models can comprise more anatomical details than the prior computer models. Several models have been constructed, for example, a highly detailed 3-D anatomically accurate computer model of the human thorax as a volume conductor utilising the US National Library of Medicine's (NLM) Visible Human Man (VHM) digital anatomy data. Based on the validation runs the developed software package is readily applicable in analysis of a wide range of bioelectric field problems.