球孢白僵菌素，由球孢白僵菌FO-6979产生，是小鼠巨噬细胞中脂滴形成的特异性抑制剂。

Beauveriolides, specific inhibitors of lipid droplet formation in mouse macrophages, produced by Beauveria sp. FO-6979.

作者信息

Namatame I, Tomoda H, Si S, Yamaguchi Y, Masuma R, Omura S

机构信息

Graduate School of Pharmaceutical Sciences, Kitasato University, and Research Center for Biological Function, The Kitasato Institute, Tokyo, Japan.

出版信息

J Antibiot (Tokyo). 1999 Jan;52(1):1-6. doi: 10.7164/antibiotics.52.1.

DOI:10.7164/antibiotics.52.1

PMID:10092189

Abstract

Beauveria sp. FO-6979, a soil isolate, was found to produce inhibitors of lipid droplet formation in mouse peritoneal macrophages. A new compound beauveriolide III was isolated along with a known compound beauveriolide I from the fermentation broth of the producing strain by solvent extraction, ODS column chromatography, silica gel column chromatography and preparative HPLC. Beauveriolides I and III caused a reduction in the number and size of cytosolic lipid droplets in macrophages at 10 microM without any cytotoxic effect on macrophages.

摘要

球孢白僵菌属菌株FO-6979是从土壤中分离得到的，研究发现其能产生抑制小鼠腹腔巨噬细胞中脂滴形成的物质。通过溶剂萃取、ODS柱色谱法、硅胶柱色谱法和制备型高效液相色谱法，从该产生菌的发酵液中分离出一种新化合物白僵菌素III以及一种已知化合物白僵菌素I。白僵菌素I和III在浓度为10微摩尔时可使巨噬细胞中胞质脂滴的数量和大小减少，且对巨噬细胞无任何细胞毒性作用。