IC202A，一种由链霉菌属1454 - 19菌株产生的具有免疫抑制活性的新型铁载体。I. 分类学、发酵、分离及生物活性。
IC202A, a new siderophore with immunosuppressive activity produced by Streptoalloteichus sp. 1454-19. I. Taxonomy, fermentation, isolation and biological activity.
作者信息
Iijima M, Someno T, Imada C, Okami Y, Ishizuka M, Takeuchi T
机构信息
Institute for Chemotherapy, MCRF, Shizuoka, Japan.
出版信息
J Antibiot (Tokyo). 1999 Jan;52(1):20-4. doi: 10.7164/antibiotics.52.20.
PMID:10092192
Abstract
IC202A, a new immunosuppressive compound, was isolated from the culture filtrate of Streptoalloteichus sp. 1454-19. It showed a suppressive effect on mixed lymphocyte culture reaction with an IC50 value of 3.6 microg/ml and mitogen induced lymphocyte blastogenesis in vitro.
摘要
新型免疫抑制化合物IC202A是从链霉菌属1454 - 19菌株的培养滤液中分离得到的。它对混合淋巴细胞培养反应具有抑制作用，IC50值为3.6微克/毫升，并且在体外对有丝分裂原诱导的淋巴细胞增殖也有抑制作用。
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