Ueno M, Iijima M, Masuda T, Kinoshita N, Iinuma H, Naganawa H, Hamada M, Ishizuka M, Takeuchi T
Institute for Chemotherapy, Microbial Chemistry Research Foundation, Shizuoka, Japan.
J Antibiot (Tokyo). 1992 Dec;45(12):1819-26. doi: 10.7164/antibiotics.45.1819.
In the course of screening for immunomodulators inhibiting the mixed lymphocyte culture reaction (MLCR), we found a novel immunosuppressant, dethymicin in mycelium of Amycolatopsis mediterranei MI710-51F6. From physico-chemical properties and biological activity it is different from immunosuppressants produced by microorganisms such as cyclosporins, FK506 and rapamycin. It inhibited immune responses in vitro and in vivo, and prolonged skin allograft in rats.
在筛选抑制混合淋巴细胞培养反应（MLCR）的免疫调节剂过程中，我们从地中海拟无枝酸菌MI710 - 51F6的菌丝体中发现了一种新型免疫抑制剂——去胸腺霉素。从物理化学性质和生物活性来看，它与环孢菌素、FK506和雷帕霉素等微生物产生的免疫抑制剂不同。它在体外和体内均能抑制免疫反应，并延长大鼠皮肤同种异体移植的存活时间。
