手术切除的伴有上皮内瘤变（VIN 3）的外阴病变中浸润性癌的发生率。
Frequency of invasive cancer in surgically excised vulvar lesions with intraepithelial neoplasia (VIN 3).
作者信息
Husseinzadeh N, Recinto C
机构信息
Division of Gynecologic Oncology, University of Cincinnati College of Medicine, Cincinnati, Ohio, 45267-0526, USA.
出版信息
Gynecol Oncol. 1999 Apr;73(1):119-20. doi: 10.1006/gyno.1998.5327.
OBJECTIVE
The aim of this study was to determine the frequency of invasive cancer found from specimens removed by surgical excision on patients with diagnosis of VIN 3.
METHODS
Seventy-eight patients with biopsy-proven vulvar intraepithelial neoplasia 3 (VIN 3) were treated by surgical excision.
RESULTS
Sixteen patients (20.5%) were found to have invasion in the excised surgical specimen. Superficial invasion was seen in 7 patients (9%), 9 were noted to have >1 mm invasion (11.5%), and 1 patient had in situ Paget's disease (1.3%).
CONCLUSION
Surgical excision should be considered a preferable method in management of patients with VIN 3.
目的
本研究的目的是确定诊断为VIN 3的患者经手术切除标本中发现浸润性癌的频率。
方法
78例经活检证实为外阴上皮内瘤变3级（VIN 3）的患者接受了手术切除治疗。
结果
16例患者（20.5%）在切除的手术标本中发现有浸润。7例患者（9%）为浅表浸润，9例患者浸润深度>1 mm（11.5%），1例患者有原位佩吉特病（1.3%）。
结论
手术切除应被视为VIN 3患者治疗的首选方法。
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