外阴上皮内瘤变III级：113例患者结局与后续侵袭性外阴癌发生情况的临床研究
Vulvar intraepithelial neoplasia III: a clinical study of the outcome in 113 cases with relation to the later development of invasive vulvar carcinoma.
作者信息
Jones R W, Rowan D M
机构信息
Department of Gynecologic Oncology, Green Lane/National Women's Hospital, Auckland, New Zealand.
出版信息
Obstet Gynecol. 1994 Nov;84(5):741-5.
OBJECTIVE
To determine the outcome of 113 women with vulvar intraepithelial neoplasia (VIN), particularly in reference to the later development of invasive vulvar carcinoma.
METHODS
All cases of VIN III seen between 1961 and 1993 were reviewed.
RESULTS
Seven of eight untreated cases of VIN III progressed to invasive vulvar cancer within 8 years, and the eighth regressed spontaneously. Four women developed invasive vulvar carcinoma 7-18 years after treatment. Thus, 3.8% of treated patients later developed invasive vulvar carcinoma, and 87.5% of untreated patients progressed to invasive carcinoma.
CONCLUSION
There is a substantial risk that untreated VIN III will progress to invasive cancer.
目的
确定113例外阴上皮内瘤变（VIN）患者的病情转归，尤其是关于浸润性外阴癌的后续发展情况。
方法
回顾了1961年至1993年间所见的所有VIN III病例。
结果
8例未经治疗的VIN III病例中有7例在8年内进展为浸润性外阴癌，第8例自发消退。4名女性在治疗后7 - 18年发生浸润性外阴癌。因此，3.8%的接受治疗患者后来发生浸润性外阴癌，87.5%的未治疗患者进展为浸润性癌。
结论
未经治疗的VIN III进展为浸润性癌的风险很大。
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