Campos A H, Schor N
Nephrology Division, Department of Medicine, Universidade Federal de São Paulo, Brazil.
Nephron. 1999;81(4):393-7. doi: 10.1159/000045322.
We investigated the in vitro effect of an aqueous extract of Phyllanthus niruri L. on a model of CaOx crystal endocytosis by Madin-Darby canine kidney cells. The extract exhibited a potent and effective non-concentration-dependent inhibitory effect on the CaOx crystal internalization. This response was present even at very high (pathologic) CaOx concentrations and no P. niruri L.-induced toxic effect could be detected. Biochemical analysis of culture media containing P. niruri L. did not provide any clues for the elucidation of the cellular pathways affected by this natural product. Although further studies are necessary for a better understanding of the role of P. niruri L. in urolithiasis, our findings show that this natural product could be an attractive alternative for the treatment of urinary stones.
我们研究了余甘子水提取物对Madin-Darby犬肾细胞草酸钙晶体胞吞作用模型的体外影响。该提取物对草酸钙晶体的内化表现出强效且非浓度依赖性的抑制作用。即使在非常高的（病理）草酸钙浓度下，这种反应依然存在，且未检测到余甘子诱导的毒性作用。对含有余甘子的培养基进行生化分析，并未为阐明这种天然产物所影响的细胞途径提供任何线索。尽管为了更好地理解余甘子在尿路结石中的作用还需要进一步研究，但我们的研究结果表明，这种天然产物可能是治疗尿路结石的一种有吸引力的替代物。
