Bednár B
Cesk Patol. 1976 May;12(2):67-71.
Tissue specimens of 46 skin wounds were taken on day 8 after a surgical operation to be given an electronoptic examination. The results were evaluated according to age groups. The best healing was the corium showing a prepondenrance of the epidermis had been regenerated with the corium showing a prepondenrance of the proliferation of fibroblasts most of them oriented across the wound direction. Nevertheless, there was a wrong neocolagen fibre orientation with the corium joined mainly by amorphous intercellular substance, probably non-fibrous soluble collangen. - Older subjects were found to have slowed down exudative and macrophagic reactions which were then seen interfering withe the proliferation of fibroblasts and their proteosynthetic activity. To a certain extent, a similar situation was also observed in children where, too, the precipitate exudative reaction was seen interfering in the fibroproliferative phase.
46例皮肤伤口的组织标本于手术8天后采集,进行电子光学检查。结果按年龄组进行评估。愈合最好的是真皮,表皮再生占优势,真皮中以成纤维细胞增殖为主,大多数成纤维细胞沿伤口方向排列。然而,新胶原纤维的排列方向错误,真皮主要由无定形细胞间物质连接,可能是无纤维的可溶性胶原。发现老年受试者的渗出和巨噬细胞反应减慢,进而干扰成纤维细胞的增殖及其蛋白质合成活性。在一定程度上,儿童也观察到类似情况,即渗出反应沉淀也干扰了纤维增生期。