Cesk Patol. 1976 Nov;12(4):180-4.
The healing of six-day-old cutaneous wounds under different conditions had been evaluated in rats. Wounds situated along the direction of cutaneous splitting displayed a slightly better healing than the other ones. In the wounds of young rats proliferation of fibroblast occurred earlier, but the more pronounced exsudative component persisted for a longer period. Regeneration of the epidermis preceded healing in the corium in all cases. All the differences mentioned disappeared when the wound was sutured two hours after the lesion had been produced, under conditions simulating the surgical procedure. The wound edges remained free of any substantial reaction. The regenerated epidermis became easily disrupted and the wound opened widely even when the histological processing was very careful. The lesioned connective tissue of the corium remained covered with fibrin.
已在大鼠中评估了不同条件下六日龄皮肤伤口的愈合情况。沿皮肤裂开方向的伤口愈合情况略优于其他伤口。幼鼠伤口中，成纤维细胞增殖较早出现，但渗出成分更明显，持续时间更长。在所有情况下，表皮再生均先于真皮愈合。当在模拟手术过程的条件下，在损伤产生两小时后缝合伤口时，上述所有差异均消失。伤口边缘未出现任何明显反应。即使组织学处理非常小心，再生的表皮也很容易破裂，伤口会大幅裂开。真皮受损的结缔组织仍被纤维蛋白覆盖。
