Sato T, Konishi K, Yabushita K, Nojima N, Kimura H, Maeda K, Tsuji M, Miwa A
Department of Surgery, Toyama Prefectural Central Hospital, Japan.
Int Surg. 1998 Oct-Dec;83(4):340-2.
The lack of any other effective treatment for colorectal liver metastases makes hepatic resection a primary treatment consideration. Between January 1980 and December 1996, 36 patients with metachronous liver metastases who underwent hepatic resection were reviewed. The age, sex, site of primary lesion, stage, size and number of hepatic metastases, and time interval between primary colorectal carcinoma resection to occurrence of liver metastases (disease-free interval, DFI) were documented. DFI was 569 days on average. Complete removal of primary colorectal cancer and metastatic liver tumour with histologically negative resection margins was accomplished in all cases. The 5 year survival rate following the first operation for primary colorectal cancer was 43.1%. The length of DFI influenced, independently, patients' prognoses based upon not only univariate but also multivariate survival analysis (P<0.01). We conclude that the DFI is the independent prognostic factor for metachronous liver metastases after curative resection of primary tumour.
由于缺乏针对结直肠肝转移的其他有效治疗方法，肝切除术成为主要的治疗考虑手段。回顾了1980年1月至1996年12月间36例行肝切除术的异时性肝转移患者。记录了患者的年龄、性别、原发灶部位、分期、肝转移灶的大小和数量，以及从原发性结直肠癌切除到出现肝转移的时间间隔（无病间期，DFI）。平均DFI为569天。所有病例均实现了原发性结直肠癌和转移性肝肿瘤的完整切除，且组织学切缘阴性。首次原发性结直肠癌手术后的5年生存率为43.1%。单因素和多因素生存分析均表明，DFI独立影响患者预后（P<0.01）。我们得出结论，DFI是原发性肿瘤根治性切除术后异时性肝转移的独立预后因素。
