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Evolution of amyloid: what normal protein folding may tell us about fibrillogenesis and disease.

作者信息

Lansbury P T

出版信息

Proc Natl Acad Sci U S A. 1999 Mar 30;96(7):3342-4. doi: 10.1073/pnas.96.7.3342.

DOI:10.1073/pnas.96.7.3342
PMID:10097040
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC34271/
Abstract
摘要

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Entropically Driven Order in Crowded Solutions:  From Liquid Crystals to Cell Biology.拥挤溶液中的熵驱动有序：从液晶到细胞生物学
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Designing conditions for in vitro formation of amyloid protofilaments and fibrils.设计体外形成淀粉样前原纤维和原纤维的条件。
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Characterization of the transthyretin acid denaturation pathways by analytical ultracentrifugation: implications for wild-type, V30M, and L55P amyloid fibril formation.通过分析超速离心法对转甲状腺素蛋白酸变性途径的表征：对野生型、V30M和L55P淀粉样原纤维形成的影响
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Neurological illness in transgenic mice expressing a prion protein with an insertional mutation.表达具有插入突变的朊病毒蛋白的转基因小鼠中的神经疾病。
Neuron. 1998 Dec;21(6):1339-51. doi: 10.1016/s0896-6273(00)80653-4.
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Watching amyloid fibrils grow by time-lapse atomic force microscopy.通过延时原子力显微镜观察淀粉样纤维的生长。
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Accelerated in vitro fibril formation by a mutant alpha-synuclein linked to early-onset Parkinson disease.与早发性帕金森病相关的突变α-突触核蛋白加速体外原纤维形成。
Nat Med. 1998 Nov;4(11):1318-20. doi: 10.1038/3311.
8
Alzheimer's beta-amyloid vasoactivity: identification of a novel beta-amyloid conformational intermediate.阿尔茨海默病β-淀粉样蛋白的血管活性：一种新型β-淀粉样蛋白构象中间体的鉴定
FEBS Lett. 1998 Oct 9;436(3):445-8. doi: 10.1016/s0014-5793(98)01170-3.
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Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions.亨廷顿蛋白在细胞核中发挥作用以诱导细胞凋亡，但细胞死亡与核内包涵体的形成并无关联。
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Ataxin-1 nuclear localization and aggregation: role in polyglutamine-induced disease in SCA1 transgenic mice.共济失调蛋白-1的核定位与聚集：在SCA1转基因小鼠多聚谷氨酰胺诱导疾病中的作用
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