Kurosaki S, Otsuka H, Kunitomo M, Koyama M, Pawankar R, Matumoto K
Department of Otolaryngology, Nippon Medical School, Kanagawa, Japan.
Nihon Ika Daigaku Zasshi. 1999 Feb;66(1):41-4. doi: 10.1272/jnms.66.41.
Delayed-type hypersensitivity with granulomatous lesions to silk sutures is rather rare. Yet, braided silk sutures often act as a non-immunologic foreign-body and cause a granulomatous inflammatory reaction years after surgery. We report here a case of recurrent granulomas with remarkable infiltration of eosinophils that may have resulted from an IgE-mediated hypersensitivity reaction to silk fibroin, a component of the braided silk suture. Under normal circumstances exposure to fibroin is rather rare. Therefore, the present patient may have developed this reaction to the silk sutures used in a previous surgery.
对丝线缝合线产生肉芽肿性病变的迟发型超敏反应相当罕见。然而，编织丝线缝合线常作为一种非免疫性异物，在手术后数年引发肉芽肿性炎症反应。我们在此报告一例复发性肉芽肿病例，其嗜酸性粒细胞显著浸润，这可能是由对编织丝线缝合线成分丝素蛋白的IgE介导的超敏反应所致。在正常情况下，接触丝素蛋白相当罕见。因此，该患者可能对先前手术中使用的丝线缝合线产生了这种反应。
