Ubaldo Armato, Ilaria Dal Prà, Anna Chiarini, Giuliano Freddi
Int J Burns Trauma. 2011;1(1):27-33. Epub 2011 Sep 3.
Presently, some view silk fibroin-based biomaterials as obsolete, being outperformed by a host of newly discovered biomaterials. But several lines of evidence support the notion that silk fibroin proteins, especially those from B. mori and spiders and their recombinant forms, particularly in the form of electrospun nanofiber scaffolds, still represent promising tools for human tissue engineering/regeneration. Inevitably, the allure of recently reported biomaterials turns away many scientists and resources from the aim of more deeply elucidating the biological interactions of the various kinds of silk fibroin nanofiber scaffolds in vivo. But, even the biological features of newly reported biomaterials are not investigated in adequate depth. Hence, collaborative efforts among biomaterialists, biomedical experts, and private firms must be undertaken on a much greater scale than hitherto done to assess the real usefulness of silk fibroin proteins, thereby allowing or denying their useful introduction into the fields of Translational Regenerative Medicine.
目前，一些人认为基于丝素蛋白的生物材料已过时，被许多新发现的生物材料超越。但有几条证据支持这样一种观点，即丝素蛋白，尤其是来自家蚕和蜘蛛的丝素蛋白及其重组形式，特别是电纺纳米纤维支架形式，仍然是人类组织工程/再生的有前途的工具。不可避免地，最近报道的生物材料的吸引力使许多科学家和资源偏离了更深入阐明各种丝素蛋白纳米纤维支架在体内生物相互作用的目标。但是，即使是新报道的生物材料的生物学特性也没有得到足够深入的研究。因此，生物材料学家、生物医学专家和私营公司之间必须比以往更大规模地开展合作，以评估丝素蛋白的实际用途，从而允许或拒绝将其有效引入转化再生医学领域。
