蜕膜肥大细胞可能参与人类早期妊娠流产的发生。
Decidual mast cells might be involved in the onset of human first-trimester abortion.
作者信息
Marx L, Arck P, Kieslich C, Mitterlechner S, Kapp M, Dietl J
机构信息
Department of Obstetrics and Gynecology, Julius-Maximilians University, Würzburg, Germany.
出版信息
Am J Reprod Immunol. 1999 Jan;41(1):34-40. doi: 10.1111/j.1600-0897.1999.tb00073.x.
PROBLEM
The aim of the present study was to identify the role of mast cells and substance P (SP)-containing nerve fibers in human decidua in normal and pathological pregnancies.
METHOD OF STUDY
We collected decidua from women undergoing termination of normal pregnancies and from abortions. The presence of mast cells and SP was detected by immunohistochemistry.
RESULTS
We observed a sparse distribution of mast cells in the normal pregnancies (36.7 tryptase+ mast cells/mm2 decidua). In the decidua from abortion, we found a dramatic increase in the number of mast cells (448.7 and 469.2 tryptase+ mast cells/mm2 decidua in primary and secondary abortions, respectively). In addition, we observed an increase of SP-positive nerve fibers in the decidua of abortions.
CONCLUSIONS
Our data suggest that decidual mast cells may play an important role in the onset of abortion, due to the production of cytokines, such as tumor necrosis factor-alpha.
问题
本研究的目的是确定肥大细胞和含P物质（SP）的神经纤维在正常和病理妊娠的人蜕膜中的作用。
研究方法
我们收集了接受正常妊娠终止手术的妇女以及流产妇女的蜕膜。通过免疫组织化学检测肥大细胞和SP的存在。
结果
我们观察到正常妊娠中肥大细胞分布稀疏（每平方毫米蜕膜中有36.7个色氨酸酶阳性肥大细胞）。在流产的蜕膜中，我们发现肥大细胞数量急剧增加（原发性和继发性流产中，每平方毫米蜕膜中分别有448.7个和469.2个色氨酸酶阳性肥大细胞）。此外，我们观察到流产蜕膜中SP阳性神经纤维增加。
结论
我们的数据表明，蜕膜肥大细胞可能因产生细胞因子（如肿瘤坏死因子-α）而在流产的发生中起重要作用。
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