Christofori G, Semb H
Research Institute of Molecular Pathology, Vienna, Austria.
Trends Biochem Sci. 1999 Feb;24(2):73-6. doi: 10.1016/s0968-0004(98)01343-7.
E-cadherin-mediated cell-cell adhesion is lost during the development of most epithelial cancers. Recent evidence indicates that the loss of E-cadherin function, besides causing loss of cell-cell adhesion, might also convey signals that actively induce tumour-cell invasion and metastasis.
在大多数上皮癌的发展过程中，E-钙黏蛋白介导的细胞间黏附丧失。最近的证据表明，E-钙黏蛋白功能的丧失，除了导致细胞间黏附丧失外，还可能传递积极诱导肿瘤细胞侵袭和转移的信号。
