del Pino V L, Bolt H M
Endokrinologie. 1976;68(2):137-42.
Rats have been treated for 6 weeks with thioacetamide (0.1% in drinking water). The biochemical changes in liver microsomal metabolism of estradiol which are similar to those observed in human liver cirrhosis become already apparent after one week of treatment. These are diminishment of hepatic microsomal cytochromes P-450 and b5, comparable decrease of 2-hydroxylation and increase of formation of estrone from estradiol. The alterations of estrogen metabolism are reversible within two weeks after ending thioacetamide treatment. These data correspond to the already well established histological response of rat liver to thioacetamide, and its reversibility.
用硫代乙酰胺（饮用水中含0.1%）对大鼠进行了6周的治疗。雌二醇肝微粒体代谢的生化变化与人类肝硬化中观察到的相似，在治疗一周后就已明显显现。这些变化包括肝微粒体细胞色素P - 450和b5减少，2 - 羟化作用相应降低，以及雌二醇生成雌酮增加。雌激素代谢的改变在硫代乙酰胺治疗结束后的两周内是可逆的。这些数据与大鼠肝脏对硫代乙酰胺已确立的组织学反应及其可逆性相符。
