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Thioacetamide-induced hepatic necrosis. II. Pharmacokinetics of thioacetamide and thioacetamide-S-oxide in the rat.

作者信息

Porter W R, Gudzinowicz M J, Neal R A

出版信息

J Pharmacol Exp Ther. 1979 Mar;208(3):386-91.

PMID:430359
Abstract
摘要

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Thioacetamide-induced hepatic necrosis. II. Pharmacokinetics of thioacetamide and thioacetamide-S-oxide in the rat.硫代乙酰胺诱导的肝坏死。II. 大鼠体内硫代乙酰胺和硫代乙酰胺 - S - 氧化物的药代动力学
J Pharmacol Exp Ther. 1979 Mar;208(3):386-91.
2
Studies of the mechanism of metabolism of thioacetamide s-oxide by rat liver microsomes.大鼠肝微粒体对硫代乙酰胺S-氧化物代谢机制的研究。
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Metabolism of thioacetamide and thioacetamide S-oxide by rat liver microsomes.大鼠肝脏微粒体对硫代乙酰胺和硫代乙酰胺S-氧化物的代谢
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Toxicokinetics and toxicity of thioacetamide sulfoxide: a metabolite of thioacetamide.硫代乙酰胺亚砜的毒代动力学与毒性：硫代乙酰胺的一种代谢产物
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[Time course of thioacetamide-induced changes in estrogen metabolism in the rat liver].[硫代乙酰胺诱导大鼠肝脏雌激素代谢变化的时间进程]
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[Reaction of the hepatic tissue of various laboratory animals to single administration of thioacetamide].[不同实验动物肝脏组织对单次给予硫代乙酰胺的反应]
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Evaluation of oxidative stress based on lipid hydroperoxide, vitamin C and vitamin E during apoptosis and necrosis caused by thioacetamide in rat liver.
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Thiono compounds. 3. Chemical oxidation of thioacetamide to a mutagenic S-oxide.硫代化合物。3. 硫代乙酰胺化学氧化为诱变的S-氧化物。
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[The thioacetamide-poisoned rat as an animal experimental model for endocrinological studies of estrogen metabolism in chronic liver injury)].[硫代乙酰胺中毒大鼠作为慢性肝损伤中雌激素代谢内分泌学研究的动物实验模型]
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