Whitty A, Borysenko C W
Protein Engineering Department, Biogen, Inc., 14 Cambridge Center, Cambridge, MA 02142, USA.
Chem Biol. 1999 Apr;6(4):R107-18. doi: 10.1016/S1074-5521(99)80034-9.
A number of reports describe small peptides, and even bona fide small organic molecules, that activate homodimeric cytokine receptors and show cytokine-like activity in vitro and in vivo. These cases can be examined in light of the mechanistic and thermodynamic principles that govern cytokine-receptor activation.
许多报告描述了一些小肽，甚至是真正的小有机分子，它们能够激活同二聚体细胞因子受体，并在体外和体内表现出类似细胞因子的活性。可以根据支配细胞因子-受体激活的机制和热力学原理来研究这些情况。
