生物膜对过氧化氢酶抑制剂3-氨基-1,2,4-三唑的抗性。
Resistance of biofilms to the catalase inhibitor 3-amino-1,2, 4-triazole.
作者信息
Lu X, Roe F, Jesaitis A, Lewandowski Z
机构信息
Center for Biofilm Engineering, Montana State University, Bozeman, Montana 59717, USA.
出版信息
Biotechnol Bioeng. 1998 Jul 20;59(2):156-62.
Consortia of catalase positive bacteria consisting of Pseudomonas aeruginosa, Pseudomonas fluorescens, and Klebsiella pneumoniae, in both the planktonic form and as biofilms, disproportionate hydrogen peroxide into oxygen and water. The biofilm, however, continued to disproportionate the hydrogen peroxide in the presence of the catalase inhibitor, 3-amino-1,2,4-triazole, while the planktonic organisms did not. While the bacterial catalase-peroxidase-dismutase system was probably responsible for the disproportionation of hydrogen peroxide in both cases, biofilms resisted inhibition of this enzyme system.
由铜绿假单胞菌、荧光假单胞菌和肺炎克雷伯菌组成的过氧化氢酶阳性细菌聚集体，无论是浮游形式还是生物膜形式，都会将过氧化氢歧化为氧气和水。然而，在过氧化氢酶抑制剂3-氨基-1,2,4-三唑存在的情况下，生物膜仍能继续使过氧化氢歧化，而浮游生物则不能。虽然在这两种情况下，细菌的过氧化氢酶-过氧化物酶-超氧化物歧化酶系统可能是过氧化氢歧化的原因，但生物膜能抵抗该酶系统的抑制作用。
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