Horowitz B, Ward S M, Sanders K M
University of Nevada School of Medicine, Department of Physiology and Cell Biology, Reno 89557, USA.
Annu Rev Physiol. 1999;61:19-43. doi: 10.1146/annurev.physiol.61.1.19.
Regulation of gastrointestinal (GI) motility is intimately coordinated with the modulation of ionic conductance expressed in GI smooth muscle and nonmuscle cells. Interstitial cells of Cajal (ICC) act as pacemaker cells and possess unique ionic conductances that trigger slow wave activity in these cells. The slow wave mechanism is an exclusive feature of ICC: Smooth muscle cells may lack the basic ionic mechanisms necessary to generate or regenerate slow waves. The molecular identification of the components for these conductances provides the foundation for a complete understanding of the ionic basis for GI motility. In addition, this information will provide a basis for the identification or development of therapeutics that might act on these channels. It is much easier to study these conductances and develop blocking drugs in expression systems than in native GI muscle cells. This review focuses on the relationship between ionic currents in native GI smooth muscle cells and ICC and their molecular counterparts.
胃肠（GI）运动的调节与胃肠平滑肌和非肌肉细胞中离子电导的调节密切相关。 Cajal间质细胞（ICC）作为起搏细胞，具有独特的离子电导，可触发这些细胞中的慢波活动。慢波机制是ICC的独特特征：平滑肌细胞可能缺乏产生或再生慢波所需的基本离子机制。这些电导成分的分子鉴定为全面理解胃肠运动的离子基础提供了基础。此外，这些信息将为鉴定或开发可能作用于这些通道的治疗方法提供依据。在表达系统中研究这些电导并开发阻断药物比在天然胃肠肌肉细胞中要容易得多。本综述重点关注天然胃肠平滑肌细胞和ICC中的离子电流与其分子对应物之间的关系。
