Calop J, Burckhart M F, Fontanges R
Eur J Toxicol Environ Hyg. 1976 Sep-Oct;9(5):271-86.
The trace elements are surrounding factors which are able to act on the yield of benzo(a)pyrene hydroxylation reaction of the hepatic tissue. This action was studied for each element and for various concentrations. The action of these elements may occurred to arylhydrocarbon hydroxylase by activating or inhibiting it, to epoxyde hydrase or to glutathione S epoxydase, favouring or inhibiting the way epoxyde dihydrodiol, and finally to arylhydrocarbon hydroxylase induction. Our results, obtained in vitro on hepatic tissue with many metallic salts, showed that some trace elements may have a cocarcinogenic action.
微量元素是能够作用于肝组织苯并(a)芘羟基化反应产率的环境因素。针对每种元素和不同浓度研究了这种作用。这些元素的作用可能通过激活或抑制芳烃羟化酶、环氧化物水解酶或谷胱甘肽S环氧化物酶，促进或抑制环氧化物二氢二醇途径，最终影响芳烃羟化酶的诱导。我们在体外使用多种金属盐对肝组织进行的研究结果表明，某些微量元素可能具有协同致癌作用。
