Masini V, Vajola F S
G Ital Cardiol. 1976;6(2):191-9.
157 cases affected with "unstable angina" and hospitalized were observed over a period of from 8 to 24 months (average observation time: 16 1/2 months). The patients were treated with: nitroderivates, beta blocking drugs (when not contra-indicated); treatment of side affects (hypertension; arrhythmias, decompensation, associated pathology, correction of risk factors of coronary heart disease). 9 cases were lost and 148 were studied for the course of the illness. 10.6% died from cardiopathy (2.8% through sudden death; 7.4% from myocardial infarction); there was a 12.1% total incidence of myocardial infarction; 50% of the cases were alive but with sumptoms of stabilized angina, whilst 32.4% were completely asymptomatic. Coronographic alterations and myocardial contractility negatively affect the course of the illness. Negative effects (disease or infarction) were not checked in the cases of stenosis of only one coronary branch. In the casuistry, there were no negative effects in patients with stenosis of one coronary branch, and in cases of two or more branches, negative effects were 28%. 41% of patients with alterations of ventrical contractility gave negative results. An asymptomatic course of the illness was checked more frequently in the intermediate stages than in angina cases.
对157例“不稳定型心绞痛”住院患者进行了为期8至24个月的观察（平均观察时间：16.5个月）。患者接受了以下治疗：硝基衍生物、β受体阻滞剂（无禁忌证时）；副作用治疗（高血压、心律失常、失代偿、相关病理、冠心病危险因素的纠正）。9例失访，148例进行了病程研究。10.6%死于心脏病（2.8%死于猝死；7.4%死于心肌梗死）；心肌梗死总发生率为12.1%；50%的病例存活但有稳定型心绞痛症状，而32.4%完全无症状。冠状动脉造影改变和心肌收缩力对病程有负面影响。仅一支冠状动脉分支狭窄的病例未出现负面影响。在病例中，单支冠状动脉分支狭窄的患者未出现负面影响，而在两支或更多支冠状动脉分支狭窄的病例中，负面影响为28%。41%心室收缩力改变的患者结果为阴性。与心绞痛病例相比，疾病的无症状病程在中间阶段更常见。
