Cotoi S, Luca C
G Ital Cardiol. 1976;6(3):433-9.
Using Lidocaine intravenously in 99 patients with atrial arrhythmias, it was observed that the drug has a regularising effect in 41 from 45 atrial arrhythmia, atrial tachycardia with block and accelerated ectopic supraventricular tachycardia, where the enhanced focal activity should be taken into account. No effect was observed in functional supraventricular tachycardia, paroxysmal atrial flutter and fibrillation and tachyarrhythmia in WPW syndrome, where the re-entry mechanism plays the major role. The effect of the drug is short lived, but may be prolonged by using the drug in perfusion or repeatedly with an intramuscular method. Lidocaine acts by depressing the enhanced atrial focal activity, and therefore may be of value in the treatment of these kinds of arrhythmias.
对99例房性心律失常患者静脉注射利多卡因后观察到，在45例房性心律失常、伴有阻滞的房性心动过速和加速性异位室上性心动过速患者中，有41例该药具有调节作用，对此应考虑到局灶性活动增强的因素。在功能性室上性心动过速、阵发性心房扑动和颤动以及预激综合征中的快速心律失常患者中未观察到该药的作用，这些情况折返机制起主要作用。该药作用持续时间短，但通过灌注用药或采用肌肉注射反复用药可使其作用时间延长。利多卡因通过抑制增强的心房局灶性活动发挥作用，因此在治疗这类心律失常中可能具有价值。
