Faye-Lund H, Larsen T E
Ore-nese-halsavdelingen, Ullevål sykehus, Oslo.
Tidsskr Nor Laegeforen. 1999 Feb 28;119(6):789-91.
Mucosal malignant melanomas in the head and neck are most frequently located in the nose and sinuses. The tumours are rare, the clinical course unpredictable and the prognosis poor. 13 patients were presented with malignant melanoma in nose and sinuses in the ENT department, Ullevål Hospital, in the course of 30 years. Average age at presentation was 72 years; there were eight women and five men. Ten patients were primarily operated, and two of these received postoperative irradiation. Three patients received only palliative treatment. Four patients are alive, observation time respectively ten, seven and approximately two years (two patients). Several of the dead patients had long observation periods before death and several had operations for recurrences. The longest observed survival was 19 years. All tumours had histological characteristics indicating aggressive growth. The material is too small and sampled over too long a period for conclusions to be drawn with regard to the effect of different treatment modalities.
头颈部黏膜恶性黑色素瘤最常发生于鼻腔和鼻窦。这类肿瘤较为罕见，临床病程难以预测，预后较差。在30年的时间里，于Ullevål医院耳鼻喉科有13例患者被诊断为鼻腔和鼻窦恶性黑色素瘤。就诊时的平均年龄为72岁；其中女性8例，男性5例。10例患者接受了初次手术，其中2例术后接受了放疗。3例患者仅接受了姑息治疗。4例患者存活，观察时间分别为10年、7年和大约2年（2例患者）。几位死亡患者在死亡前有较长的观察期，还有几位因复发接受了手术。观察到的最长生存期为19年。所有肿瘤的组织学特征均显示生长侵袭性强。由于样本量太小且取材时间跨度太长，无法就不同治疗方式的效果得出结论。
