Chittajallu R, Braithwaite S P, Clarke V R, Henley J M
Department of Anatomy, Medical School, University of Bristol, UK.
Trends Pharmacol Sci. 1999 Jan;20(1):26-35. doi: 10.1016/s0165-6147(98)01286-3.
Although it is well established that kainate receptors constitute an entirely separate group of proteins from AMPA receptors, their physiological functions remain unclear. The molecular cloning of subunits that form kainate receptors and the ability to study recombinant receptors is leading to an increased understanding of their functional properties. Furthermore, the development of kainate receptor-selective agonists and antagonists over the past few years is now allowing the physiological roles of these receptors and, in some cases, specific subunits to be investigated. As a consequence, the synaptic activation of postsynaptic kainate receptors and the presence of presynaptic kainate receptors that serve to regulate excitatory and inhibitory synaptic transmission have been described, and will be discussed in this article by Ramesh Chittajallu, Steven Braithwaite, Vernon Clarke and Jeremy Henley.
尽管已经明确海人酸受体构成了与AMPA受体完全不同的一组蛋白质，但其生理功能仍不清楚。形成海人酸受体的亚基的分子克隆以及研究重组受体的能力，正使人们对其功能特性有了更多的了解。此外，在过去几年中，海人酸受体选择性激动剂和拮抗剂的开发，现在使得能够研究这些受体以及某些情况下特定亚基的生理作用。因此，已经描述了突触后海人酸受体的突触激活以及用于调节兴奋性和抑制性突触传递的突触前海人酸受体的存在，Ramesh Chittajallu、Steven Braithwaite、Vernon Clarke和Jeremy Henley将在本文中对此进行讨论。
