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谷氨酸受体5（GluK5）在视杆光感受器中的突触前定位表明，高亲和力谷氨酸受体在哺乳动物视网膜中具有新功能。

Presynaptic localization of GluK5 in rod photoreceptors suggests a novel function of high affinity glutamate receptors in the mammalian retina.

作者信息

Haumann Iris, Junghans Dirk, Anstötz Max, Frotscher Michael

机构信息

Institute of Neuroanatomy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Institute of Embryology and Stem Cell Biology, Department of Biomedicine, University of Basel, Basel, Switzerland.

出版信息

PLoS One. 2017 Feb 24;12(2):e0172967. doi: 10.1371/journal.pone.0172967. eCollection 2017.

DOI:10.1371/journal.pone.0172967
PMID:28235022
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5325551/
Abstract

Kainate receptors mediate glutamatergic signaling through both pre- and presynaptic receptors. Here, we studied the expression of the high affinity kainate receptor GluK5 in the mouse retina. Double-immunofluoresence labeling and electron microscopic analysis revealed a presynaptic localization of GluK5 in the outer plexiform layer. Unexpectedly, we found GluK5 almost exclusively localized to the presynaptic ribbon of photoreceptor terminals. Moreover, in GluK5-deficient mutant mice the structural integrity of synaptic ribbons was severely altered pointing to a novel function of GluK5 in organizing synaptic ribbons in the presynaptic terminals of rod photoreceptors.

摘要

海人酸受体通过突触前和突触后受体介导谷氨酸能信号传导。在此，我们研究了高亲和力海人酸受体GluK5在小鼠视网膜中的表达。双重免疫荧光标记和电子显微镜分析显示GluK5在外侧网状层的突触前定位。出乎意料的是，我们发现GluK5几乎只定位于光感受器终末的突触前带。此外，在GluK5缺陷型突变小鼠中，突触带的结构完整性严重改变，这表明GluK5在杆状光感受器突触前终末组织突触带方面具有新功能。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b557/5325551/64b32ce926eb/pone.0172967.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b557/5325551/b6661216d295/pone.0172967.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b557/5325551/08e869e3774c/pone.0172967.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b557/5325551/314b631de1fc/pone.0172967.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b557/5325551/64b32ce926eb/pone.0172967.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b557/5325551/b6661216d295/pone.0172967.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b557/5325551/08e869e3774c/pone.0172967.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b557/5325551/314b631de1fc/pone.0172967.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b557/5325551/64b32ce926eb/pone.0172967.g004.jpg

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Invest Ophthalmol Vis Sci. 2015 Apr;56(4):2312-24. doi: 10.1167/iovs.15-16654.
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Localization of kainate receptors in inner and outer hair cell synapses.海人酸受体在内耳毛细胞和外耳毛细胞突触中的定位。
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Presynaptic [Ca(2+)] and GCAPs: aspects on the structure and function of photoreceptor ribbon synapses.
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