Turjanski N, Lees A J, Brooks D J
MRC Cyclotron Unit, Hammersmith Hospital, London, UK.
Neurology. 1999 Mar 23;52(5):932-7. doi: 10.1212/wnl.52.5.932.
To use PET to study striatal dopaminergic function in restless legs syndrome (RLS).
RLS is a common disorder experienced by as much as 5% of the population. It has been suggested that this condition is associated with a disturbance of dopaminergic transmission.
The authors measured nigrostriatal terminal dopamine storage with 18F-dopa and striatal D2 receptor binding with 11C-raclopride PET in 13 RLS patients, five of whom were receiving treatment with L-dopa at the time of scanning. RLS results were compared with those of age-matched control subjects.
Mean caudate and putamen 18F-dopa uptake were mildly reduced in the RLS patients compared with control subjects, and this reached significance (p = 0.04) in the putamen. Mean D2 binding was reduced in the caudate (p = 0.01) and the putamen (p = 0.008) in RLS patients compared with control subjects. Six of the 13 RLS patients had caudate and putamen D2 binding reduced below the control range. Three other RLS patients showed only reduced putamen D2 binding. There were no significant differences in striatal 18F-dopa uptake or D2 binding between L-dopa-naive and L-dopa-treated RLS patients.
These PET findings support the hypothesis of central dopaminergic dysfunction in RLS.
利用正电子发射断层扫描（PET）研究不宁腿综合征（RLS）患者纹状体多巴胺能功能。
不宁腿综合征是一种常见疾病，多达5%的人群受其影响。有观点认为，该病与多巴胺能传递障碍有关。
作者用18F - 多巴测量13例不宁腿综合征患者黑质纹状体终末多巴胺储存情况，并用11C - 雷氯必利PET测量纹状体D2受体结合情况，其中5例患者在扫描时正在接受左旋多巴治疗。将不宁腿综合征患者的结果与年龄匹配的对照受试者的结果进行比较。
与对照受试者相比，不宁腿综合征患者尾状核和壳核的平均18F - 多巴摄取轻度降低，壳核的这种降低具有统计学意义（p = 0.04）。与对照受试者相比，不宁腿综合征患者尾状核（p = 0.01）和壳核（p = 0.008）的平均D2结合降低。13例不宁腿综合征患者中有6例尾状核和壳核的D2结合低于对照范围。另外3例不宁腿综合征患者仅显示壳核D2结合降低。未接受左旋多巴治疗的不宁腿综合征患者和接受左旋多巴治疗的不宁腿综合征患者在纹状体18F - 多巴摄取或D2结合方面无显著差异。
这些PET研究结果支持不宁腿综合征存在中枢多巴胺能功能障碍的假说。
