Hillenbrand R, Molthagen M, Montag D, Schachner M
Department of Neurobiology, Swiss Federal Institute of Technology, Hönggerberg, CH-8093 Zürich, Switzerland.
Eur J Neurosci. 1999 Mar;11(3):813-26. doi: 10.1046/j.1460-9568.1999.00496.x.
The close homologue of L1 (CHL1), a member of the L1 family of neural adhesion molecules, is first expressed at times of neurite outgrowth during brain development, and is detectable in subpopulations of neurons, astrocytes, oligodendrocyte precursors and Schwann cells of the mouse and rat. Aggregation assays with CHL1-transfected cells show that CHL1 does not promote homophilic adhesion or does it mediate heterophilic adhesion with L1. CHL1 promotes neurite outgrowth by hippocampal and small cerebellar neurons in substrate-bound and soluble form. The observation that CHL1 and L1 show overlapping, but also distinct patterns of synthesis in neurons and glia, suggests differential effects of L1-like molecules on neurite outgrowth.
L1神经黏附分子家族成员L1的紧密同源物（CHL1），在脑发育过程中神经突生长时首次表达，并且在小鼠和大鼠的神经元、星形胶质细胞、少突胶质细胞前体和雪旺细胞亚群中可检测到。用CHL1转染细胞进行的聚集试验表明，CHL1既不促进同源性黏附，也不介导与L1的异源性黏附。CHL1以底物结合形式和可溶性形式促进海马和小脑小神经元的神经突生长。CHL1和L1在神经元和神经胶质细胞中显示出重叠但也不同的合成模式，这一观察结果表明L1样分子对神经突生长有不同的影响。
