褪黑素增强异烟肼对结核分枝杆菌的活性。
Potentiation of isoniazid activity against Mycobacterium tuberculosis by melatonin.
作者信息
Wiid I, Hoal-van Helden E, Hon D, Lombard C, van Helden P
机构信息
MRC Centre For Molecular and Cellular Biology, Department of Medical Biochemistry, University of Stellenbosch Medical School, Tygerberg, South Africa.
出版信息
Antimicrob Agents Chemother. 1999 Apr;43(4):975-7. doi: 10.1128/AAC.43.4.975.
Abstract
The limited number of effective antituberculosis drugs available necessitates optimizing current treatments. We show that melatonin, which is synthesized in the pineal gland, can cause at least a threefold increase in the efficacy of isoniazid. This suggests that tuberculosis chemotherapy can be improved by innate molecules such as melatonin.
摘要
可用的有效抗结核药物数量有限，因此有必要优化当前的治疗方法。我们发现，由松果体合成的褪黑素可使异烟肼的疗效至少提高三倍。这表明，像褪黑素这样的内源性分子可以改善结核病化疗。
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