酮内酯类药物HMR 3647[应为HMR 3647]和HMR 3004[应为HMR 3004]、左氧氟沙星以及其他喹诺酮类和大环内酯类药物对奈瑟菌属和卡他莫拉菌的体外活性。
In vitro activities of ketolides HMR 3647 [correction of HRM 3647] and HMR 3004 [correction of HRM 3004], levofloxacin, and other quinolones and macrolides against Neisseria spp. and Moraxella catarrhalis.
作者信息
Sáez-Nieto J A, Vázquez J A
机构信息
Servicio de Bacteriología, Instituto de Salud Carlos III, Madrid, Spain.
出版信息
Antimicrob Agents Chemother. 1999 Apr;43(4):983-4. doi: 10.1128/AAC.43.4.983.
Abstract
In vitro activities of the ketolides HMR 3647 [corrected] and HMR 3004 [corrected] against pathogenic Neisseria gonorrhoeae and N. meningitidis, saprophytic Neisseria isolates, and Moraxella catarrhalis were determined. The comparison of ketolide activities with those of the other macrolides shows a much better activity in the majority of species, with macrolide MICs at which 90% of the isolates are inhibited between 8- and 10-fold higher.
摘要
测定了酮内酯类药物HMR 3647[校正后]和HMR 3004[校正后]对致病性淋病奈瑟菌和脑膜炎奈瑟菌、腐生性奈瑟菌分离株以及卡他莫拉菌的体外活性。将酮内酯类药物的活性与其他大环内酯类药物的活性进行比较，结果显示在大多数菌种中，酮内酯类药物的活性要好得多，其他大环内酯类药物抑制90%分离株的最低抑菌浓度（MIC）要高出8至10倍。
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