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通过最低抑菌浓度（MIC）测定和时间-杀菌试验，比较HMR 3647与五种药物对流感嗜血杆菌和卡他莫拉菌的活性。

Activity of HMR 3647 compared to those of five agents against Haemophilus influenzae and moraxella catarrhalis by MIC determination and time-kill assay.

作者信息

Pankuch G A, Hoellman D B, Lin G, Bajaksouzian S, Jacobs M R, Appelbaum P C

机构信息

Department of Pathology (Clinical Microbiology), Hershey Medical Center, Hershey, Pennsylvania 17033, USA.

出版信息

Antimicrob Agents Chemother. 1998 Nov;42(11):3032-4. doi: 10.1128/AAC.42.11.3032.

DOI:10.1128/AAC.42.11.3032
PMID:9797250
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC105990/
Abstract

The microdilution MICs of HMR 3647, erythromycin A, azithromycin, clarithromycin, roxithromycin, and pristinamycin against 50/90% of 249 Haemophilus influenzae and 50 Moraxella catarrhalis isolates were 2/4, 0.06/0.125; 8/16, 0.25/0.25; 2/4, 0.06/0.125; 16/16, 0.25/0.25; 32/>32, 1/2; and 2/4, 0.5/0.5 microg/ml. Azithromycin was bactericidal against all 10 H. influenzae and 3 of 5 M. catarrhalis isolates and HMR 3647, erythromycin A, clarithromycin, roxithromycin, and pristinamycin were bacteriostatic, against all 15 strains after 24 h at the MIC.

摘要

HMR 3647、红霉素A、阿奇霉素、克拉霉素、罗红霉素和 pristinamycin 对249株流感嗜血杆菌和50株卡他莫拉菌分离株中50/90%菌株的微量稀释法最低抑菌浓度（MIC）分别为2/4、0.06/0.125；8/16、0.25/0.25；2/4、0.06/0.125；16/16、0.25/0.25；32/>32、1/2；以及2/4、0.5/0.5微克/毫升。阿奇霉素对所有10株流感嗜血杆菌和5株卡他莫拉菌分离株中的3株具有杀菌作用，而HMR 3647、红霉素A、克拉霉素、罗红霉素和pristinamycin在MIC浓度下作用24小时后对所有15株菌株均具有抑菌作用。

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mefE is necessary for the erythromycin-resistant M phenotype in Streptococcus pneumoniae.mefE基因对于肺炎链球菌中耐红霉素的M表型是必需的。
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