锂对大鼠食物摄入量的影响。

The effect of lithium on food intake in rats.

作者信息

Opitz K, Schäfer G

出版信息

Int Pharmacopsychiatry. 1976;11(4):197-205. doi: 10.1159/000468234.

Abstract

The influence of lithium on ingestive behavior and body weight was studied in male and female rats. Single i.p. doses of LiCl (3.6-7.2 mmol/kg) reduced both food intake and water consumption. Repeated large doses of LiCl given intraperitoneally caused a prompt anorexia and delayed polydipsia as well as weight loss, effects that were much more pronounced in male than in female rats. Small doses of LiCl on the other hand, increased food intake and body weight during long-term treatment. The findings indicate that an increase in food intake can account for the increased body weight sometimes seen in rats given lithium.

摘要

在雄性和雌性大鼠中研究了锂对摄食行为和体重的影响。腹腔注射单次剂量的LiCl（3.6 - 7.2 mmol/kg）可减少食物摄入量和饮水量。腹腔内反复给予大剂量LiCl会导致迅速的厌食、延迟的烦渴以及体重减轻，这些效应在雄性大鼠中比在雌性大鼠中更为明显。另一方面，在长期治疗期间，小剂量的LiCl会增加食物摄入量和体重。研究结果表明，食物摄入量的增加可以解释有时在给予锂的大鼠中出现的体重增加现象。