Smith D F, Amdisen A
Acta Pharmacol Toxicol (Copenh). 1983 Feb;52(2):81-5. doi: 10.1111/j.1600-0773.1983.tb03407.x.
Male rats received LiCl for one week either by continuous intracerebroventricular injection from osmotic minipumps or by oral administration in the diet. Control groups received corresponding treatment with NaCl. The intracerebroventricular lithium treatment produced relatively high lithium levels in brain regions (0.6-2.3 mmol/kg) and negligible lithium levels in plasma (less than 0.1 mmol/l) while the oral treatment produced moderate lithium levels in brain regions as well as in blood (0.5-0.9 mmol/kg and 0.5-0.75 mmol/l, respectively). Body weight loss and enhanced water intake occurred in groups given oral lithium treatment as well as in those given lithium via minipumps. The results suggest that administration of lithium by minipumps may be of use to study central actions of lithium.
雄性大鼠通过渗透微型泵持续脑室内注射或在饮食中口服给予氯化锂一周。对照组接受相应的氯化钠治疗。脑室内锂治疗在脑区产生相对较高的锂水平（0.6 - 2.3 mmol/kg），而血浆中的锂水平可忽略不计（低于0.1 mmol/l），而口服治疗在脑区以及血液中产生中等水平的锂（分别为0.5 - 0.9 mmol/kg和0.5 - 0.75 mmol/l）。口服锂治疗组以及通过微型泵给予锂的组均出现体重减轻和饮水量增加。结果表明，通过微型泵给予锂可能有助于研究锂的中枢作用。
