Brown S T
J Am Vener Dis Assoc. 1976 Dec;3(2 Pt 2):136-42.
There are few studies of therapy for secondary syphilis which are adequate by modern standards of scientific design. Penicillin has been the best documented, effective antibiotic, although not all forms and regimens are equally effective. Although both aqueous penicillin G and procaine penicillin G in oil with aluminum monostearate (PAM) appear effective, these are not practical penicillin forms. The first requires injections every 2 to 4 hours for 7 to 10 days and the latter is no longer available in the United Sates. Aqueous procaine penicillin G (APPG) regimes have been evaluated in limited trials, but do appear effective. However, APPG requires daily injections and is impractical for widespread use in the treatment of secondary syphilis. The injection of 2.4 million units of benzathine penicillin G appears to be an effective single session regimen. Although tetracycline is widely accepted as the drug of choice for patients allergic to penicillin, this drug has been less rigorously evaluated for treatment of secondary syphilis. Other antibiotics have been even less well evaluated and none has been clearly shown to be highly effective.
按照现代科学设计标准，对二期梅毒治疗的研究很少。青霉素是记录最完善、有效的抗生素，不过并非所有剂型和治疗方案都同样有效。虽然水溶性青霉素G和含单硬脂酸铝的油剂普鲁卡因青霉素G（PAM）似乎都有效，但这些都不是实用的青霉素剂型。前者需要每2至4小时注射一次，持续7至10天，而后者在美国已不再有供应。水溶性普鲁卡因青霉素G（APPG）治疗方案在有限的试验中得到了评估，但确实显示出有效。然而，APPG需要每日注射，在二期梅毒治疗中广泛使用不太实际。注射240万单位苄星青霉素G似乎是一种有效的单次治疗方案。虽然四环素被广泛认为是对青霉素过敏患者的首选药物，但该药物在二期梅毒治疗方面的评估不够严格。其他抗生素的评估则更不完善，而且没有一种被明确证明具有高效性。
