Changes of ion mobilizations and their related enzyme activities in the blood of fluoride-intoxicated rats.

Fluoride concentrations in plasma 3 hr after a single oral dose of NaF (5 mg/100 g body weight) were increased 26 times above the control, but the concentrations in erythrocytes and red cell membranes were increased only 1.8 and 1.5 times over the respective control levels. Ionic concentrations of magnesium and calcium in erythrocytes and their membranes were significantly changed by fluoride administration, but the ionic concentrations in plasma were not statistically changed in comparison with controls. Acid phosphatase activities in plasma and erythrocytes were significantly decreased by fluoride administration, but alkaline phosphatase activity in the plasma was not changed. Mg2+-activated ATPase activity was significantly elevated in the erythrocyte membrane by fluoride administration; (Na+ + K+)-activated ATPase activity was significantly decreased in the membrane.