Suketa Y, Mikami E, Sato Y, Hayashi M, Yamamoto T
J Toxicol Environ Health. 1976 Nov;2(2):301-9. doi: 10.1080/15287397609529434.
Fluoride concentrations in plasma 3 hr after a single oral dose of NaF (5 mg/100 g body weight) were increased 26 times above the control, but the concentrations in erythrocytes and red cell membranes were increased only 1.8 and 1.5 times over the respective control levels. Ionic concentrations of magnesium and calcium in erythrocytes and their membranes were significantly changed by fluoride administration, but the ionic concentrations in plasma were not statistically changed in comparison with controls. Acid phosphatase activities in plasma and erythrocytes were significantly decreased by fluoride administration, but alkaline phosphatase activity in the plasma was not changed. Mg2+-activated ATPase activity was significantly elevated in the erythrocyte membrane by fluoride administration; (Na+ + K+)-activated ATPase activity was significantly decreased in the membrane.
单次口服氟化钠（5毫克/100克体重）3小时后，血浆中的氟化物浓度比对照组增加了26倍，但红细胞和红细胞膜中的浓度仅比各自的对照水平增加了1.8倍和1.5倍。给予氟化物后，红细胞及其膜中的镁离子和钙离子浓度发生了显著变化，但与对照组相比，血浆中的离子浓度没有统计学上的变化。给予氟化物后，血浆和红细胞中的酸性磷酸酶活性显著降低，但血浆中的碱性磷酸酶活性没有变化。给予氟化物后，红细胞膜中的Mg2+激活的ATP酶活性显著升高；膜中的（Na+ + K+）激活的ATP酶活性显著降低。
