Serebrovskaia Iu A, Ustinova S E
Kardiologiia. 1976 Nov;16(11):70-7.
Studies of plasma renin activity performed by way of radioimmunoassay in 44 patients with essential hypertension permitted to subdivide the patients with Stage 2 disease into 2 groups: Group 1 with normal or elevated plasma renin activity, and Group 2 -- with sub-normal activity. A statistically significant reverse relationship was found between the age of the hypertensive patients and their plasma renin activity; this parameter tends to decrease along with the increasing duration of the disease. With paralled determinations of renin activity by way of radioimmunoassay and biological method in 20 patients a positive correlation was established; the figures obtained by radioimmunoassay were twice as high as those obtained by the biological technique. A radioimmunological determination of the concentration of angiotensin II in 14 patients with essential hypertension and in 4 normals permitted to reveal its elevation over the level of the normals in 10 of the patients. Positive correlation was established between the renin activity and the angiotensin II concentration.
通过放射免疫分析法对44例原发性高血压患者的血浆肾素活性进行研究，从而将2期高血压患者分为两组：第1组血浆肾素活性正常或升高，第2组活性低于正常。高血压患者的年龄与其血浆肾素活性之间存在统计学上显著的负相关关系；该参数往往随着疾病持续时间的增加而降低。通过放射免疫分析法和生物学方法对20例患者的肾素活性进行平行测定，结果显示二者呈正相关；放射免疫分析法得到的数据是生物学技术所得数据的两倍。对14例原发性高血压患者和4例正常人的血管紧张素II浓度进行放射免疫测定，结果显示10例患者的血管紧张素II浓度高于正常水平。肾素活性与血管紧张素II浓度之间呈正相关。
