Aurell M, Pettersson M, Berglund G
Lancet. 1975 Aug 23;2(7930):342-5. doi: 10.1016/s0140-6736(75)92780-4.
In a random sample of normotensive and hypertensive fifty-year-old men plasma-renin-activity (P.R.A.), plasma-renin-concentration (P.R.C.), and renin substrate were measured using radioimmunoassay for angiotensin I. P.R.A. in normotensives and untreated hypertensives were normally distributed with slight skewness to the right. The mean P.R.A. for untreated hypertensives (0.65 ng. per ml. per hour) was slightly, but not significantly, lower than that of the normotensive reference group (0.78 ng. per ml. per hour). Previously untreated hypertensives who had been off treatment for four weeks had either high or low P.R.A. depending on the previous treatment. No differences in the angiotensin-generation rate were noted as judged from the P.R.A./P.R.C. ratio. No differences in the renin-substrate concentration between the groups were found. The findings suggest that renin changes in essential hypertenion are secondary to pressure changes. Thus, the renin-angiotensin system may not be of primary pathogenetic importance in the development of essential hypertension.
在一组血压正常和高血压的50岁男性随机样本中，使用放射免疫分析法测定血管紧张素I来检测血浆肾素活性（P.R.A.）、血浆肾素浓度（P.R.C.）和肾素底物。血压正常者和未经治疗的高血压患者的P.R.A.呈正态分布，略有右偏态。未经治疗的高血压患者的平均P.R.A.（每毫升每小时0.65纳克）略低于血压正常的参照组（每毫升每小时0.78纳克），但差异不显著。此前未经治疗的高血压患者停药四周后，其P.R.A.根据之前的治疗情况呈现高或低的状态。根据P.R.A./P.R.C.比值判断，未发现血管紧张素生成率有差异。两组之间的肾素底物浓度未发现差异。这些发现表明，原发性高血压中肾素的变化继发于血压变化。因此，肾素-血管紧张素系统在原发性高血压的发生发展中可能不具有主要的致病重要性。
