Dydek G J, Souney P F, Matthews S J
Kimbrough Army Community Hospital, Fort Meade, MD.
Hosp Formul. 1992 Feb;27(2):185-91.
In this retrospective study of 30 patients with urinary tract infections, a drug usage evaluation indicated that 60% of the patient population sampled were appropriately switched to ciprofloxacin from IV antimicrobial agents; inappropriate use was identified in 40%. The drug's safety profile indicates that patients can be safely removed from IV antimicrobial therapy and continue treatment on ciprofloxacin, a measure which reduces treatment costs. These costs also can be lowered when inappropriate ciprofloxacin use is ruled out in patients with organisms sensitive to less costly oral antimicrobials. Identifying which patients should be removed from parenteral therapy maximizes the economic benefit of ciprofloxacin therapy and optimizes the impact of pharmacy intervention on patient care.
在这项针对30例尿路感染患者的回顾性研究中，药物使用评估表明，抽样患者群体中有60%从静脉用抗菌药物适当转换为环丙沙星；40%存在用药不当情况。该药物的安全性表明，患者可安全地停止静脉用抗菌治疗，继续使用环丙沙星进行治疗，这一措施可降低治疗成本。对于感染对成本较低的口服抗菌药物敏感的微生物的患者，排除环丙沙星的不当使用时，这些成本也可降低。确定哪些患者应停止肠外治疗可使环丙沙星治疗的经济效益最大化，并优化药学干预对患者护理的影响。
