给大鼠注射3-甲基胆蒽和苯巴比妥后肝尿苷二磷酸葡萄糖醛酸转移酶活性功能异质性的证明。
Demonstration of functional heterogeneity of hepatic uridine diphosphate glucuronosyltransferase activities after administration of 3-methylcholanthrene and phenobarbital to rats.
作者信息
Wishart G J
出版信息
Biochem J. 1978 Aug 15;174(2):671-2. doi: 10.1042/bj1740671.
Abstract
After the administration of 3-methylcholanthrene to adult male rats, activities of hepatic UDP-glucuronosyltransferase towards six from a group of 12 substrates were stimulated by 250-350%. Activities towards the remaining six substrates were unaffected. Conversely, after phenobarbital administration, activities formerly stimulated by 3-methylcholanthrene remained unchanged, and the other six activities were stimulated by 160-280%. The relationship of these two groups of transferase activities to other evidence suggesting the same heterogeneity of the enzyme is discussed.
摘要
给成年雄性大鼠注射3-甲基胆蒽后，肝脏UDP-葡萄糖醛酸基转移酶对一组12种底物中6种底物的活性提高了250%-350%。对其余6种底物的活性则未受影响。相反，注射苯巴比妥后，先前由3-甲基胆蒽刺激的活性保持不变，而其他6种活性提高了160%-280%。讨论了这两组转移酶活性与其他表明该酶具有相同异质性的证据之间的关系。
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本文引用的文献
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Effects of phenobarbital and 3-methylcholanthrene on substrate specificity of rat liver microsomal UDP-glucuronyltransferase.苯巴比妥和3-甲基胆蒽对大鼠肝微粒体UDP-葡萄糖醛酸基转移酶底物特异性的影响。
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Steroid and non-steroid UDP glucuronyltransferase: glucuronidation of synthetic estrogens as steroids.类固醇和非类固醇尿苷二磷酸葡萄糖醛酸基转移酶：合成雌激素作为类固醇的葡萄糖醛酸化作用。
J Steroid Biochem. 1977 Aug;8(8):867-72. doi: 10.1016/0022-4731(77)90096-6.
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