类固醇激素和外源性化学物质对Wistar大鼠中针对雄甾酮和4-硝基苯酚的UDP-葡萄糖醛酸基转移酶活性青春期发育的影响。
Effects of steroid hormones and xenobiotics on the pubertal development of UDP-glucuronosyltransferase activities towards androsterone and 4-nitrophenol in Wistar rats.
作者信息
Watanabe H K, Matsui M
出版信息
Biochem J. 1984 Sep 1;222(2):321-6. doi: 10.1042/bj2220321.
Oestradiol benzoate, testosterone propionate, progesterone, corticosterone, 3-methylcholanthrene and phenobarbital were administered to Wistar rats at the pubertal period, and their effects on hepatic UDP-glucuronosyltransferase activities were determined. Pretreatment with oestradiol benzoate had a temporary suppressive effect on androsterone UDP-glucuronosyltransferase activity in rats with the high-activity phenotype of androsterone glucuronidation. The effect was marked in 40-day-old rats, but was not found in older rats. Androsterone UDP-glucuronosyltransferase activity was induced by phenobarbital in rats with the high-activity phenotype, but not in rats with the low-activity phenotype. Foster-feeding experiments showed that breast milk did not alter the genetically determined expression of androsterone UDP-glucuronosyltransferase activity in Wistar rats. In contrast, 4-nitrophenol UDP-glucuronosyltransferase activity was not affected by steroid hormones, but was highly induced by 3-methylcholanthrene.
在青春期给Wistar大鼠注射苯甲酸雌二醇、丙酸睾酮、孕酮、皮质酮、3-甲基胆蒽和苯巴比妥，并测定它们对肝脏UDP-葡萄糖醛酸基转移酶活性的影响。用苯甲酸雌二醇预处理对具有雄甾酮葡萄糖醛酸化高活性表型的大鼠的雄甾酮UDP-葡萄糖醛酸基转移酶活性有暂时的抑制作用。这种作用在40日龄大鼠中很明显，但在年龄较大的大鼠中未发现。苯巴比妥可诱导具有高活性表型的大鼠的雄甾酮UDP-葡萄糖醛酸基转移酶活性，但不能诱导具有低活性表型的大鼠的该酶活性。寄养实验表明，母乳不会改变Wistar大鼠中雄甾酮UDP-葡萄糖醛酸基转移酶活性的遗传决定表达。相反，4-硝基苯酚UDP-葡萄糖醛酸基转移酶活性不受类固醇激素影响，但受到3-甲基胆蒽的高度诱导。
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